Restylane® and PERLANE® are cosmetic dermal fillers that replace volume and restore youthful contours to the skin to smooth away moderate to severe facial wrinkles and folds, such as the lines from the nose to the corners of the mouth (nasolabial folds). Restylane® and Perlane have well-defined safety profiles. Restylane® has been used in over 1.4 million treatments in the U.S. and is available in more than 70 countries. It is the most studied dermal filler in the world with dozens of publications in the medical literature. Clinical studies have shown no significant differences in the safety of Restylane® and Perlane. Restylane® and Perlane are made of . In the human body, natural hyaluronic acid provides volume and fullness to the skin.